Molecular Epigenetics

in Bremen

The research of my group focuses on DNA, RNA and protein methyltransferases. One main research aim is to understand the reaction mechanism and mode of action of different classes of methyltransferases. We have long experience in enzyme design by rational and directed evolution approaches and succeeded in changing the target base and DNA sequence specificity of different DNA methyltransferases. Powerful methods of recombinant expression of enzymes and assaying methyl transfer reactions are established. Enzyme characterization is performed by sophisticated biomolecular interaction and kinetic methods. Using these methods we try to understand the catalytic and substrate recognition mechanism of various DNA methyltransferases and improve their properties for biotechnological applications. In addition, we study the role of DNA methylation and other epigenetic marks in development and disease.
http://www.jacobs-university.de/ses/ajeltsch/

Technologien

DNA methylation analysis Rohde, C., Zhang, Y., Reinhardt, R., & Jeltsch, A. (2010) BMC Bioinformatics 11, 230. Zhang, Y., Rohde, C., Reinhardt, R., Voelcker-Rehage, C. & Jeltsch, A. (2009) Genome Biology 10, R138. Zhang, Y., Rohde, C., Tierling, S., Jurkowski, T.P., Bock, C., Santacruz, D., Reinhardt, R., Groth, M., Walter, J. & Jeltsch, A. (2009) PLOS Genet. 5, e1000438. Rohde, C., Zhang, Y., Stamerjohanns, H., Hecher, K., Reinhardt, R. & Jeltsch, A. (2009) Biotechniques 47, 781-3. Rohde, C., Zhang, Y, Jurkowski, T.P., Stamerjohanns, H., Reinhardt, R., & Jeltsch, A. (2008) Nucl. Acids Res. 36, e34. Peptide arrays Dhayalan, A., Rajavelu, A., Rathert, P., Tamas, R., Jurkowska, R.Z., Ragozin, S. & Jeltsch, A. (2010) J. Biol. Chem., in press. Zhang, Y., Jurkowska, R., Soeroes, S., Rajavelu, A., Dhayalan, A., Bock, I., Rathert, P., Brandt, O., Reinhardt, R., Fischle, W., & Jeltsch, A. (2010) Nucl. Acids Res., in press Rathert, P., Zhang, X., Cheng, X. & Jeltsch, A. (2008) Nat. Chem. Biol. 4, 344-6. Rathert, P., Zhang, X., Freund, C., Cheng, X. & Jeltsch, A. (2008) Chemistry & Biology 15, 5-11. Enzymology of DNA methyltransferases Dhayalan, A., Rajavelu, A., Rathert, P., Tamas, R., Jurkowska, R.Z., Ragozin, S. & Jeltsch, A. (2010) J. Biol. Chem., in press. Zhang, Y., Jurkowska, R., Soeroes, S., Rajavelu, A., Dhayalan, A., Bock, I., Rathert, P., Brandt, O., Reinhardt, R., Fischle, W., & Jeltsch, A. (2010) Nucl. Acids Res., in press Jurkowska, R.Z., Anspach, N., Urbanke, C., Jia, D., Reinhardt, R., Nellen, W., Cheng, X., & Jeltsch, A. (2008) Nucleic Acids Res. 36, 6656-63. Jeltsch, A. (2008) Nat. Struct. Mol. Biol. 15, 1003-4. Métivier, R., Gallais, R., Tiffoche, C., Le Péron, C., Jurkowska, R.Z., Carmouche, R. P., Barath, P., Demay, F., Reid, G., Jeltsch, A., Gannon, F., & Salbert, G. (2008) Nature 452, 45-50. Goyal, R., Reinhardt, R., & Jeltsch, A. (2006) Nucl. Acids Res. 34, 1182-8. Gowher, H., Loutchanwoot, P., Vorobjeva, O., Handa, V., Jurkowska, R.Z., Jurkowski, T.P., & Jeltsch, A. (2006) J. Mol. Biol. 357, 928-41. Handa, V. & Jeltsch, A. (2005) J. Mol. Biol. 348, 1103-12. Gowher, H., Liebert, K., Hermann, A., Xu, G., & Jeltsch, A. (2005) J. Biol. Chem. 280, 13341-8. Hermann, A., Goyal, R. & Jeltsch, A. (2004) J. Biol. Chem. 279, 48350-9.

Publikationen

Most important recent publications of Albert Jeltsch

• Jeltsch, A. (2010) Phylogeny of Methylomes. Science 328, 837-8.
• Zhang, Y., Rohde, C., Reinhardt, R., Voelcker-Rehage, C. & Jeltsch, A. (2009) Genome Biology 10, R138.
• Zhang, Y., Rohde, C., Tierling, S., Jurkowski, T.P., Bock, C., Santacruz, D., Reinhardt, R., Groth, M., Walter, J. & Jeltsch, A. (2009) PLOS Genet. 5, e1000438.

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Kontakt

Prof. Dr. Albert Jeltsch
Professor of Biochemistry
Research II
Jacobs University Bremen
Campus Ring 1
28759 Bremen, Germany

Telefon: +49 421 200 3247
Fax: +49 421 200 3249

Email: