Molecular Epigenetics
in BremenThe research of my group focuses on DNA, RNA and protein methyltransferases. One main research aim is to understand the reaction mechanism and mode of action of different classes of methyltransferases. We have long experience in enzyme design by rational and directed evolution approaches and succeeded in changing the target base and DNA sequence specificity of different DNA methyltransferases. Powerful methods of recombinant expression of enzymes and assaying methyl transfer reactions are established. Enzyme characterization is performed by sophisticated biomolecular interaction and kinetic methods. Using these methods we try to understand the catalytic and substrate recognition mechanism of various DNA methyltransferases and improve their properties for biotechnological applications. In addition, we study the role of DNA methylation and other epigenetic marks in development and disease.
Technologies
DNA methylation analysis
Rohde, C., Zhang, Y., Reinhardt, R., & Jeltsch, A. (2010) BMC Bioinformatics 11, 230.
Zhang, Y., Rohde, C., Reinhardt, R., Voelcker-Rehage, C. & Jeltsch, A. (2009) Genome Biology 10, R138.
Zhang, Y., Rohde, C., Tierling, S., Jurkowski, T.P., Bock, C., Santacruz, D., Reinhardt, R., Groth, M., Walter, J. & Jeltsch, A. (2009) PLOS Genet. 5, e1000438.
Rohde, C., Zhang, Y., Stamerjohanns, H., Hecher, K., Reinhardt, R. & Jeltsch, A. (2009) Biotechniques 47, 781-3.
Rohde, C., Zhang, Y, Jurkowski, T.P., Stamerjohanns, H., Reinhardt, R., & Jeltsch, A. (2008) Nucl. Acids Res. 36, e34.
Peptide arrays
Dhayalan, A., Rajavelu, A., Rathert, P., Tamas, R., Jurkowska, R.Z., Ragozin, S. & Jeltsch, A. (2010) J. Biol. Chem., in press.
Zhang, Y., Jurkowska, R., Soeroes, S., Rajavelu, A., Dhayalan, A., Bock, I., Rathert, P., Brandt, O., Reinhardt, R., Fischle, W., & Jeltsch, A. (2010) Nucl. Acids Res., in press
Rathert, P., Zhang, X., Cheng, X. & Jeltsch, A. (2008) Nat. Chem. Biol. 4, 344-6.
Rathert, P., Zhang, X., Freund, C., Cheng, X. & Jeltsch, A. (2008) Chemistry & Biology 15, 5-11.
Enzymology of DNA methyltransferases
Dhayalan, A., Rajavelu, A., Rathert, P., Tamas, R., Jurkowska, R.Z., Ragozin, S. & Jeltsch, A. (2010) J. Biol. Chem., in press.
Zhang, Y., Jurkowska, R., Soeroes, S., Rajavelu, A., Dhayalan, A., Bock, I., Rathert, P., Brandt, O., Reinhardt, R., Fischle, W., & Jeltsch, A. (2010) Nucl. Acids Res., in press
Jurkowska, R.Z., Anspach, N., Urbanke, C., Jia, D., Reinhardt, R., Nellen, W., Cheng, X., & Jeltsch, A. (2008) Nucleic Acids Res. 36, 6656-63.
Jeltsch, A. (2008) Nat. Struct. Mol. Biol. 15, 1003-4.
Métivier, R., Gallais, R., Tiffoche, C., Le Péron, C., Jurkowska, R.Z., Carmouche, R. P., Barath, P., Demay, F., Reid, G., Jeltsch, A., Gannon, F., & Salbert, G. (2008) Nature 452, 45-50.
Goyal, R., Reinhardt, R., & Jeltsch, A. (2006) Nucl. Acids Res. 34, 1182-8.
Gowher, H., Loutchanwoot, P., Vorobjeva, O., Handa, V., Jurkowska, R.Z., Jurkowski, T.P., & Jeltsch, A. (2006) J. Mol. Biol. 357, 928-41.
Handa, V. & Jeltsch, A. (2005) J. Mol. Biol. 348, 1103-12.
Gowher, H., Liebert, K., Hermann, A., Xu, G., & Jeltsch, A. (2005) J. Biol. Chem. 280, 13341-8.
Hermann, A., Goyal, R. & Jeltsch, A. (2004) J. Biol. Chem. 279, 48350-9.
Publications
Most important recent publications of Albert Jeltsch
• Jeltsch, A. (2010) Phylogeny of Methylomes. Science 328, 837-8.
• Zhang, Y., Rohde, C., Reinhardt, R., Voelcker-Rehage, C. & Jeltsch, A. (2009) Genome Biology 10, R138.
• Zhang, Y., Rohde, C., Tierling, S., Jurkowski, T.P., Bock, C., Santacruz, D., Reinhardt, R., Groth, M., Walter, J. & Jeltsch, A. (2009) PLOS Genet. 5, e1000438.
(…)
• Jeltsch, A. (2010) Phylogeny of Methylomes. Science 328, 837-8.
• Zhang, Y., Rohde, C., Reinhardt, R., Voelcker-Rehage, C. & Jeltsch, A. (2009) Genome Biology 10, R138.
• Zhang, Y., Rohde, C., Tierling, S., Jurkowski, T.P., Bock, C., Santacruz, D., Reinhardt, R., Groth, M., Walter, J. & Jeltsch, A. (2009) PLOS Genet. 5, e1000438.
(…)
Contact
Prof. Dr. Albert
Jeltsch
Professor of Biochemistry
Research II
Jacobs University Bremen
Campus Ring 1
28759 Bremen, Germany
Phone: +49 421 200 3247
Fax: +49 421 200 3249
Email:
Professor of Biochemistry
Research II
Jacobs University Bremen
Campus Ring 1
28759 Bremen, Germany
Phone: +49 421 200 3247
Fax: +49 421 200 3249
Email: