Chromatin Biology

in München

The Müller group studies the biochemical mechanisms by which chromatin-modifying enzymes and chromatin-binding proteins regulate gene transcription. In particular, their work has been focused on the mechanisms of Polycomb group and trithorax group proteins, two evolutionary conserved sets of chromatin regulators that control a plethora of developmental processes in both animals and plants. Polycomb group proteins function as transcriptional repressors that keep target genes inactive in cells where these genes should not be expressed, while trithorax group proteins maintain the same target genes active in cells where they must be expressed. The Müller group uses Drosophila as model organism and employs an integrated experimental approach that combines genetics, biochemistry, biophysics and genomics.
in progress


Selected Publications:

Scheuermann, J.C., Gaytán de Ayala Alonso, A., Oktaba, K., Ly-Hartig, N, McGinty, R.K., Fraterman, S., Wilm, M., Muir, T.W. and Müller, J. (2010). Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature 465, 243-247.

Gambetta, M.C., Oktaba, K. and Müller, J. (2009). Essential role of the glycosyltransferase Sxc/Ogt in Polycomb repression. Science 325, 93-96.



Dr. Jürg Müller
Max-Planck Institute of Biochemistry
Department of Chromatin and Chromosome Biology
Am Klopferspitz 18
82152 Martinsried