Histone modifications, linker Histone H1, chromatin architecture

in Freiburg

One of the major goals of post-genomic biology is to understand the molecular basis and physiological role of covalent protein modifications. We are using histones and the "histone code" as models to study protein modifications. Our aim is to identify new modifications, to decipher how these modifications are epigenetically inherited and how they can regulate gene expression and chromatin structure.


Schneider, R. and Grosschedl, R. (2007) Dynamics of nuclear architecture in genome organisation and gene expression. Genes Dev., 21, 3027-3043.

Izzo, A., Kamienariaz, K. and Schneider, R. (2008) The histone H1 family: specific members, specific functions. Biol. Chem., 389, 333-343.

Hajkova, P., Waldmann, T. *, Ancelin, K. *, Lange, U.C., Lacoste, N., Cesari, F., Lee, C., Almouzni, G., Schneider, R. and Surani, A. (2008) Histone replacement underlies the process of epigenetic reprogramming in the mouse germ line. Nature, 452, 877-881.


Dr. Robert Schneider
Max-Planck-Institute of Immunobiology
Stübeweg 51
D-79108 Freiburg, Germany

Phone: +49 761 5108 378
Fax: +49 761 5108 221