Structure of Interphase Chromosomes

in Berlin

The organization of the interphase chromosome is inherited over cell generations as seen by the pattern of bands and interbands on polytene chromosomes, that reproducibly forms in different tissues and stages of development. The open chromatin of interbands is established by proteins with specific structural and enzymatic properties and is stabilized by elements insulating the spreading of nearby condensed chromatin. Starting from the molecularly characterized interband protein Z4, the aim of the project was to study the role and mechanistic interaction of interband specific proteins in establishing open chromatin structure. General mechanisms of boundary formation between chromosomal band/interband domains and in the formation of insulator elements were another focus of our project.


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Prof. Dr. Harald Saumweber, AG-Leiter
Institut für Biologie, Abt. Zytogenetik
Humboldt Universität zu Berlin
Chausseestr. 117, 10115 Berlin, Germany

Phone: +49 30 2093817 8
Fax: +49 30 2093817 7