Mechanisms of epigenetic regulation of tumor suppressor genes

in Gießen

Epigenetic silencing of tumor suppressor genes is one of the most relevant molecular alterations, which occurs during carcinogenesis. It is clear that the inactivation state is maintained by aberrant DNA methylation and a repressive chromatin structure at the promoter. However mechanisms that cause this aberrant gene silencing are enigmatic.


DNA Methylation


1. The RASSF proteins in cancer; from epigenetic silencing to functional characterization. Richter AM, Pfeifer GP, Dammann RH. Biochim Biophys Acta. 2009 Mar 31.

2. Frequent occurrence of RASSF1A promoter hypermethylation and merkel cell polyomavirus in merkel cell carcinoma. Helmbold P, Lahtz C, Enk A, Herrmann-Trost P, Marsch WC, Kutzner H, Dammann RH. Mol Carcinog. 2009 Mar 26.

3. RASSF1A mediates p21Cip1/Waf1-dependent cell cycle arrest and senescence through modulation of the Raf-MEK-ERK pathway and inhibition of Akt. Thaler S, Hähnel PS, Schad A, Dammann R, Schuler M. Cancer Res. 2009 Mar 1;69(5):1748-57.



Prof. Dr. Reinhard Dammann
Institut für Genetik
Heinrich-Buff-Ring 58
D-35392 Gießen, Germany

Phone: +49 641-99-35462
Fax: +49 641-99-35469