Molecular Mechanisms of Chromatin Plasticity

in München

Our Department investigates the nuclear processes that allow organisms to react and adapt to a variety of environmental changes. In particular, we are interested in the identification and analysis of mechanisms that dynamically regulate chromatin structure and transcription, with a keen focus on the role of cellular metabolites, signalling networks and mitochondrial function. Of future interest is how aging, stresses such as DNA damage and animal behaviour condition gene activity and nuclear function.
We perform most of our studies in model systems as yeast, Drosophila and mammalian cells. Our collaborative and interdisciplinary working style includes methods range from structural biology, genomics, life-cell imaging and physiological approaches.


The chaperone-histone partnership: for the greater good of histone traffic and chromatin plasticity. Hondele M., Ladurner A. Curr Opin Struct Biol. 2011 Nov. 2

PARG: A Macrodomain in Disguise. Hassler M, Jankevicius G, Ladurner AG. Structure. 2011 Oct 12;19(10):1351-3.

Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79. Ehrentraut S, Hassler M, Oppikofer M, Kueng S, Weber JM, Mueller JW, Gasser SM, Ladurner AG, Ehrenhofer-Murray AE. Genes Dev. 2011 Sep 1;25(17):1835-46.



Prof. Dr. Andreas Ladurner
Butenandtstr. 5, Gebäude B 81337 München

Phone: 089 2180 77095
Fax: 089 2180 77093