Epigenetic reprogramming; DNA-methylation; Epigenomics

in Saarbrücken

Research areas and current projects of the group:

The interdisciplinary research focusses on developmental and disease-related processes linked to DNA-methylation. The current projects areas are:

Epigenetic reprogramming:
We investigate the principles and mechanisms of epigenetic program changes during the earliest stages of ammamlian development and their relevance for stem cell generation.

Regulation of imprinted genes:
We analyse the structural and regulatory peculiarities of imprinted genes and the consequences of epigenetic misregulation on human diseases.

We develop new assays and approaches (experimentally and conceptionally) to decipher epigenetic profiles along chromosomes and apply those technologies to developmental and disease related biomedical systems.


Bisulphite-Sequencing, MeDIP, Comparative epigenomics, Immunohistochemistry in early mouse embryos, Functional molecular assays


1: Zhang Y, Rohde C, Tierling S, Jurkowski TP, Bock C, Santacruz D, Ragozin S,
Reinhardt R, Groth M, Walter J, Jeltsch A. DNA methylation analysis of chromosome
21 gene promoters at single base pair and single allele resolution. PLoS Genet.
2009 Mar;5(3):e1000438. Epub 2009 Mar 27. PubMed PMID: 19325872; PubMed Central
PMCID: PMC2653639.

2: Lepikhov K, Zakhartchenko V, Hao R, Yang F, Wrenzycki C, Niemann H, Wolf E,



Prof. Dr. Jörn Walter
Universität des Saarlandes
FR 8.2 Genetik
Postfach 151150
66041 Saarbrücken, Germany

Phone: +49 681 302 4367
Fax: +49 681 302 2703