Epigenetik, DNA Methylierung, Ataxien (SCA), M. Parkinson, Genbank (GEPARD)

in Bonn

The Neurobiology Laboratory at the Department of Neurology, University Bonn investigates the molecular, cellular and pharmacological aspects of the pathogenesis of neurodegenerative disorders with special emphasis on the cerebellar ataxias, Parkinson's disease and Multiple System Atrophy (MSA). Current research projects focus on the molecular mechanism of neuronal cell death in these disorders in comparison to normal aging and the pathophysiology of trinucleotide repeat disorders with particular interest in differentially regulated gene expression, gene expression profiling and epigentic mechanisms.
With a particular focus on spinocerebellar ataxia type 3 (SCA3), one of eight neurodegenerative disorders caused by an unstable CAG repeat expansion in the coding gene region, resulting in an expanded polyglutamine tract in the corresponding protein, ataxin-3, we analyze the molecular steps leading to neurodegeneration and the physiological protein functions. We have developed transgenic models using inducible high-level expression of non-expanded or expanded human full-length disease proteins, a AT3 knockout mouse and are currently resolving the physiological function of the respective proteins which are involved in key celullar mechanisms such as nucleocytoplasmic-shuttling, ER-stress and the ubiquitin proteasom system.
http://www.neurologie.uni-bonn.de/wuellner.htm

Technologien

We analyze the molecular steps leading to neurodegeneration and the physiological protein functions. We have developed transgenic models, employ a wide array of techniques in molecular biology and epigenetics

Publikationen

RECENT PUBLICATONS


1: Schmitt I, Wüllner U, van Rooyen JP, Khazneh H, Becker J, Volk A, Kubisch C,
Becker T, Kostic VS, Klein C, Ramirez A. Variants in the 3'UTR of SNCA do not
affect miRNA-433 binding and alpha-synuclein expression. Eur J Hum Genet. 2012
May 23. doi: 10.1038/ejhg.2012.84. [Epub ahead of print] PubMed PMID: 22617348.


2: Weng MK, Zimmer B, Pöltl D, Broeg MP, Ivanova V, Gaspar JA, Sachinidis A,

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Kontakt

Prof. Dr. Ullrich Wüllner, Stellv. Direktor
Klinik und Poliklinik für Neurologie
Universitätsklinikum Bonn
Sigmund-Freud-Straße 25
53105 Bonn

Telefon: x49 (0) 228 2871 5712 / 5697
Fax: x49 (0) 228 2871 5024

Email: