DNA methylation and chromatin regulators in urological cancers

in Düsseldorf

Alterations of DNA methylation in bladder and prostate cancers, especially hypomethylation of retroelements; the mechanisms causing them and their effects on biological and clinical properties of the cancers; their relation to changes in specific chromatin regulator proteins
http://www.uniklinik-duesseldorf.de/deutsch/unternehmen/kliniken/urologischeklinik/ForschungundLehre/Forschungslabor/page.html

Technologies

Verschiedene Methoden zur Analyse der DNA-Methylierung, Gen- und Proteinexpression Zellkulturtechniken für normale und transformierte Zellen des Urogenitaltrakts

Publications

1: Schulz WA, Hoffmann MJ. Epigenetic mechanisms in the biology of prostate
cancer. Semin Cancer Biol. 2009 Jun;19(3):172-80. Epub 2009 Feb 20. Review.
PubMed PMID: 19429481.

2: Ramachandran K, Gopisetty G, Gordian E, Navarro L, Hader C, Reis IM, Schulz
WA, Singal R. Methylation-mediated repression of GADD45alpha in prostate cancer
and its role as a potential therapeutic target. Cancer Res. 2009 Feb

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Contact

Prof. Dr. rer. nat. Wolfgang Schulz
Urologische Klinik Heinrich Heine Universität Moorenstr. 5 40225 Düsseldorf

Phone: 0211-81-18966
Fax: 0211-81-15846

Email: