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• Akhtar Becker Bock, Lengauer Buiting, Horsthemke Cardoso Dammann

Group Ehrenhofer-Murray

Establishment of chromatin domains in S. cerevisiae

in Essen

The goal of our research is to understand how eukaryotic cells organize their genetic material into chromatin in the nucleus. Differences in chromatin packaging dictate when and where genes are expressed within an organism, and which genomic regions become permanently repressed (silenced). Among others, the basic units of chromatin, the histones, are modified by specialized enzymes (e.g. acetylation, methylation), which changes the binding characteristics of other factors to chromatin. We are investigating the molecular mechanisms of how chromatin influences DNA functions in the model organisms Saccharomyces cerevisiae (bakers yeast) and Drosophila (fruit fly). We seek to understand how organisms ensure the correct temporal and spatial expression of genes, which is crucial for normal growth and development.

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