Mechanisms of epigenetic regulation of tumor suppressor genes
in GießenEpigenetic silencing of tumor suppressor genes is one of the most relevant molecular alterations, which occurs during carcinogenesis. It is clear that the inactivation state is maintained by aberrant DNA methylation and a repressive chromatin structure at the promoter. However mechanisms that cause this aberrant gene silencing are enigmatic.
Technologies
DNA Methylation
Publications
1. The RASSF proteins in cancer; from epigenetic silencing to functional characterization. Richter AM, Pfeifer GP, Dammann RH. Biochim Biophys Acta. 2009 Mar 31.
2. Frequent occurrence of RASSF1A promoter hypermethylation and merkel cell polyomavirus in merkel cell carcinoma. Helmbold P, Lahtz C, Enk A, Herrmann-Trost P, Marsch WC, Kutzner H, Dammann RH. Mol Carcinog. 2009 Mar 26.
3. RASSF1A mediates p21Cip1/Waf1-dependent cell cycle arrest and senescence through modulation of the Raf-MEK-ERK pathway and inhibition of Akt. Thaler S, Hähnel PS, Schad A, Dammann R, Schuler M. Cancer Res. 2009 Mar 1;69(5):1748-57.
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2. Frequent occurrence of RASSF1A promoter hypermethylation and merkel cell polyomavirus in merkel cell carcinoma. Helmbold P, Lahtz C, Enk A, Herrmann-Trost P, Marsch WC, Kutzner H, Dammann RH. Mol Carcinog. 2009 Mar 26.
3. RASSF1A mediates p21Cip1/Waf1-dependent cell cycle arrest and senescence through modulation of the Raf-MEK-ERK pathway and inhibition of Akt. Thaler S, Hähnel PS, Schad A, Dammann R, Schuler M. Cancer Res. 2009 Mar 1;69(5):1748-57.
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Contact
Prof. Dr. Reinhard
Dammann
Institut für Genetik
Justus-Liebig-Universitaet
Heinrich-Buff-Ring 58
D-35392 Gießen, Germany
Phone: +49 641-99-35462
Fax: +49 641-99-35469
Email:
Institut für Genetik
Justus-Liebig-Universitaet
Heinrich-Buff-Ring 58
D-35392 Gießen, Germany
Phone: +49 641-99-35462
Fax: +49 641-99-35469
Email: