Chromatin dynamics and genome regulation

in München

The team studies a variety of regulatory principles in chromatin biology, predominantly using the Drosophila model. We blend methodology ranging from hard-core biochemistry, to advanced microscopy and (reverse) genetics to come to an in-depth understanding of structres and mechanisms.
One strong focus is on the functioning of ATP-dependent chromatin remodelling machines, including mechanistic, physiological and developmentl aspects.
A second focus centres on subtle. yet vital mechanism of transcriptional fine tuning through chromatin structure modulation, using the Drosophila dosage compensation system as a model. We are interested in the roles of long, regulatory RNA molecules in this process.
http://www.molekularbiologie.abi.med.uni-muenchen.de/ueber_uns/becker/index.html

Technologies

In vitro reconstitution of nucleosomes and chromatin fibres. Nucleosome remodelling assays. Global mapping of chromosome interactors by Chromatin immunoprecipitation (ChIP)..

Publications

see pubmed entries: Becker-PB

Contact

Prof. Dr. Peter Becker
Prof. Dr. Peter B. Becker, ML
Adolf-Butenandt-Institut
- Molekularbiologie -
Schillerstr. 44
80336 München

Phone: Tel: +49-89-2180 75-427/ Tel
Fax: +49-89-2180 75-425

Email: